Stem cells from schizophrenic patients produce fewer neurons

neurons from schizonephric stem cells

Japanese researchers identified abnormal brain development in schizophrenia using stem cells from schizophrenics. The study shows a genetic mutation in schizophrenia impairs the differentiation of neurons. This abnormal differentiation causes an imbalance between the number of neurons and astrocytes in the brain. While … Continue reading

Stem Cells also Rust

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Oxygen in the air is well known to cause damaging rust on cars through a process known as oxidation. Similarly, a research group at Lund University in Sweden, has now identified that certain cells during embryonic development also are negatively … Continue reading

Human stem cells treat spinal cord injury side effects in mice

human stem cell transplant in mice for spinal cord injury treatment

People with spinal cord injuries suffer from many complications in addition to paralysis and numbness. Researchers recently found that human stem cell-derived interneuron precursors alleviate two of the most severe side effects -bladder dysfunction and chronic neuropathic pain- in mice. … Continue reading

Breakthrough in production of dopamine neurons for Parkinson’s disease

Dopamine neurons differentiated from human embryonic stem cells

The first transplantation of stem cell-derived dopamine neurons in patients with Parkinson’s disease is almost within reach. However, it remains a challenge for researchers to control stem cells accurately in the lab in order to achieve successful and functional stem … Continue reading

Hacking the programs of cancer stem cells

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All tumor cells are the offspring of a single, aberrant cell, but they are not all alike. Only a few retain the capacity of the original cell to create an entire tumor. Such cancer stem cells can migrate to other … Continue reading

End ‘stem cell tourism,’ experts urge

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The continued marketing and use of experimental stem cell-based interventions inside and outside the United States is problematic and unsustainable, according to a new paper by science policy and bioethics experts at Rice University’s Baker Institute for Public Policy and … Continue reading

New studies question the treatment of female infertility with stem cells

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  It has been claimed that a treatment for female infertility will be available by stem cell therapy. But a new study by Swedish researchers from the University of Gothenburg and Karolinska Institutet published in Nature Medicine questions whether new … Continue reading

Researchers urge lifting of NIH funding restrictions on chimeric research

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Citing the “tremendous potential” of research on human stem cells in nonhuman embryos, scientists and a bioethicist from the Stanford University School of Medicine have co-authored a letter urging the removal of funding restrictions imposed on such research last month … Continue reading

Study rejects biologic age as limiting factor for stem cell transplants in AML patients

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  More than 40 percent of older patients with acute myeloid leukemia (AML) can remain in long-term cancer remission through a modified, less aggressive approach to donor stem cell transplantation, according to the results of a phase 2 study led … Continue reading

Questionable stem-cell treatment case still under investigation

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A Winnipeg researcher who inflated his credentials and charged multiple sclerosis patients tens of thousands of dollars for questionable overseas stem-cell treatment has made international headlines while Canadian investigations into his conduct drag on. Nearly a year after several MS … Continue reading

Study redefines how stem cells make blood

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Stem-cell scientists led by Dr. John Dick have discovered a completely new view of how human blood is made, upending conventional dogma from the 1960s. The findings, published in the journal Science, prove “that the whole classic ‘textbook’ view we … Continue reading

Researchers uncover diverse subtypes of serotonin-producing neurons

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It used to be enough to call a serotonergic neuron a serotonergic neuron. These brain cells make the neurotransmitter serotonin, which helps regulate mood, appetite, breathing rate, body temperature and more. Recently, however, scientists have begun to learn that these … Continue reading

Stem-cell derived neurons may ameliorate cognitive impairments in Alzheimer’s disease

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In a recent study researchers have used human embryonic stem cells derived neurons to ameliorate cognitive functions of mice afflicted with Alzheimer’s disease. A team in Shanghai found that by transplanting neurons derived from the cells into the rodents they … Continue reading

Reserachers identified a new gene keeping stem cells in check

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When it comes to stem cells, too much of a good thing isn’t wonderful: producing too many new stem cells may lead to cancer; producing too few inhibits the repair and maintenance of the body. In a paper published in … Continue reading

New York Stem Cell Foundation announces $7.5 million to five stem cell researchers

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The New York Stem Cell Foundation (NYSCF) announced the 2015 class of NYSCF – Robertson Investigators, selecting five of the most talented scientists. Each Investigator will receive a $1.5 million award, disbursed over the next five years. The award enables … Continue reading

Stem Cell Therapy Protects Bone in Lupus

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Lupus is an autoimmune disease. People with lupus suffer from fatigue, joint pain and swelling and also have a markedly increased risk of developing osteoporosis. Clinical trials have shown that receiving a transplant of mesenchymal stem cells can greatly improve … Continue reading

Hacking off-the-shelf 3-D printer towards rebuilding the heart

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As of this month, over 4,000 Americans are on the waiting list to receive a heart transplant. With failing hearts, these patients have no other options; heart tissue, unlike other parts of the body, is unable to heal itself once … Continue reading

Serotonin Promotes Regeneration of Spinal Motor Neurons

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Tropical fish may hold clues that could aid research into motor neuron disease and paralysis caused by spinal cord injury. Scientists have discovered that a hormone called serotonin -better known for its role as a mood booster- can help zebrafish … Continue reading

NHS growing stem cells for ground breaking diabetes treatment

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NHS Blood and Transplant will start producing stem cells for groundbreaking treatment aimed at combating one of the most serious health problems facing the NHS, diabetic kidney disease. The disease is a major cause of sickness and death in the … Continue reading

Blocking differentiation is enough to give cells ‘stemness’

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Though immune therapy and regenerative medicine are promising areas of research for future medical therapies, they are limited today by the difficulty of creating stem cells. Scientists around the world are searching for ways to create somatic stem cells in … Continue reading

Thyroid Function May Be Restored by Using Patient-Derived Human Cells

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A discovery made by investigators from Beth Israel Deaconess Medical Center (BIDMC) and the Boston University School of Medicine (BUSM) may help lead to the development of a cell-based regenerative therapy to restore thyroid function in patients with cancer who … Continue reading

Cardiac muscle cells as good as progenitors for heart repair

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Stem cell therapies for post-heart attack tissue repair are at best modestly successful. Most clinical trials have used bone marrow-derived cells, which are thought to promote the growth of new blood vessels in the damaged heart, but many of these … Continue reading

A step forward in obtaining blood stem cells in laboratory

Copyright @ ZEISS Microscopy, "Human blood with red blood cells, T cells (orange) and platelets (green)" Flickr. CC BY-NC-ND 2.0

A new study led by researchers from IMIM (Hospital del Mar Medical Research Institute) may make it possible to produce cells that can be used for haematological transplants in patients with no compatible donors in the future. The study is … Continue reading

Half-matched donor bone marrow transplant is just as good as a full match

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When it comes to treating blood cancers like leukemia and lymphomas, new research shows that a half-matched donor bone marrow transplant may be just as good as a full match. Bone marrow transplantation is a life-saving therapy for many patients … Continue reading

Single-cell transcriptomics reveals new insights in pluripotency

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Researchers on the Wellcome Genome Campus reveal new genes involved in stem cell pluripotency, new subpopulations of cells and new methods to find meaning in the data. The findings have implications for the study of early development. Stem cells exist … Continue reading

Hydrogels boost ability of stem cells to restore eyesight and heal brains

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Researchers show that engineered ‘hydrogels’ not only help with stem cell transplantation, but actually speed healing in both the eye and brain University of Toronto scientists and engineers have made a breakthrough in cell transplantation using a gel-like biomaterial that … Continue reading

Stem cells cure blindness

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Glaucoma Visual Fields Improve Following Stem Cell Treatment The Stem Cell Ophthalmology Treatment Study (SCOTS) uses bone marrow derived adult stem cells for the treatment of optic nerve and retinal disease. It is the largest stem cell study in ophthalmology … Continue reading

Amniotic stem cells show healing potential

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Amniotic stem cells demonstrate healing potential In new experiments, the lab of bioengineer Jeffrey Jacot combined versatile amniotic stem cells with injectable hydrogels used as scaffolds in regenerative medicine. The research revealed these stem cells enhance the development of vessels. … Continue reading

Stem cell graft techniques have similar effects for facelifting

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Two Different Fat Graft Techniques Have Similar Effects on Facial Skin A recent study showed that two approaches to fat grafting—injection of fat cells versus fat-derived stem cells— used for facelifting in cosmetic surgery have similar effects in reversing the … Continue reading